Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9vs NY MetsL  0-2 0-1
4/11vs NY MetsW  3-1 1-1
4/12vs NY MetsL  1-2 1-2
4/15at MontrealL  4-5 1-3
4/16at MontrealL  0-7 1-4
4/17at PhiladelphiaL  2-6 1-5
4/18at PhiladelphiaL  3-4
10
1-6
4/19at PhiladelphiaL  3-7 1-7
4/20at StL CardinalsL  1-6 1-8
4/21at StL CardinalsL  0-8 1-9
4/22at StL CardinalsL  0-3 1-10
4/24vs PhiladelphiaL  4-6 1-11
4/25vs PhiladelphiaL  5-7 1-12
4/26vs PhiladelphiaL  2-6 1-13
4/29vs StL CardinalsW  6-1 2-13
5/1vs AtlantaL  1-2 2-14
5/2vs AtlantaW  5-2 3-14
5/3vs AtlantaL  7-9 3-15
5/4vs HoustonL  4-5 3-16
5/5vs HoustonL  3-4 3-17
5/6vs HoustonW  2-1
11
4-17
5/7vs HoustonL  0-6 4-18
5/8at AtlantaL  3-4
11
4-19
5/9at AtlantaW  7-3 5-19
5/12at CincinnatiL  1-2 5-20
5/13at CincinnatiL  3-8 5-21
5/14at CincinnatiL  1-6 5-22
5/15at HoustonL  0-5 5-23
5/16at HoustonL  1-6 5-24
5/17at HoustonL  1-6 5-25
5/19vs CincinnatiL  0-5 5-26
5/20vs CincinnatiL  7-10 5-27
5/21vs CincinnatiW  5-1 6-27
5/22vs MontrealL  3-6 6-28
5/23vs MontrealW  6-4 7-28
5/24vs MontrealW  6-2 8-28
5/25vs PittsburghW  10-9
11
9-28
5/26vs PittsburghL  4-6 9-29
5/27vs PittsburghL  2-3 9-30
5/28vs PittsburghL  4-9 9-31
5/29at NY MetsL  1-6 9-32
5/30at NY MetsW  10-3 10-32
5/31at NY MetsL  2-3 10-33
6/2at PittsburghL  3-16 10-34
6/3at PittsburghL  2-3 10-35
6/4at PittsburghL  4-5
10
10-36
6/5vs LA DodgersW  4-3 11-36
6/6vs LA DodgersW  11-5 12-36
6/7vs LA DodgersL  0-7 12-37
6/9vs San FranciscoW  2-1 13-37
6/10vs San FranciscoW  7-4 14-37
6/11vs San FranciscoW  6-1 15-37
8/10vs NY MetsL  5-7
13
15-38
8/11vs NY MetsL  2-4 15-39
8/12vs NY MetsL  4-7
10
15-40
8/13vs NY MetsW  6-1 16-40
8/15vs PittsburghW  4-3
15
17-40
8/16vs PittsburghL  3-4
11
17-41
8/16vs PittsburghW  6-4 18-41
8/17vs LA DodgersW  3-1 19-41
8/18vs LA DodgersL  0-5 19-42
8/19vs LA DodgersW  4-3 20-42
8/21vs San FranciscoL  3-4 20-43
8/22vs San FranciscoL  1-2 20-44
8/23vs San FranciscoW  6-5 21-44
8/24vs San DiegoW  9-8
11
22-44
8/25vs San DiegoW  4-3 23-44
8/26vs San DiegoW  9-7 24-44
8/27at LA DodgersL  0-6 24-45
8/28at LA DodgersL  1-6 24-46
8/29at LA DodgersW  3-1 25-46
8/30at LA DodgersW  2-1 26-46
8/31at San DiegoL  1-4 26-47
9/1at San DiegoL  2-3 26-48
9/2at San DiegoL  4-5
10
26-49
9/3at San FranciscoL  0-12 26-50
9/4at San FranciscoL  2-3
10
26-51
9/5at San FranciscoW  8-2 27-51
9/6at San FranciscoL  0-3 27-52
9/7at StL CardinalsW  10-0 28-52
9/8at StL CardinalsW  4-3
12
29-52
9/9at StL CardinalsW  7-3 30-52
9/11vs MontrealW  6-5 31-52
9/12vs MontrealL  0-2 31-53
9/13vs MontrealL  6-10 31-54
9/15vs PittsburghL  2-8 31-55
9/18at MontrealL  0-11 31-56
9/19at MontrealW  2-1 32-56
9/20at MontrealL  0-4 32-57
9/21vs StL CardinalsL  0-2 32-58
9/22vs StL CardinalsW  4-3 33-58
9/23vs NY MetsW  2-1 34-58
9/24vs NY MetsW  10-9 35-58
9/25vs PhiladelphiaL  2-9 35-59
9/27vs PhiladelphiaL  2-5 35-60
9/27vs PhiladelphiaW  14-0 36-60
9/28at PittsburghL  0-4 36-61
9/28at PittsburghW  3-1 37-61
9/29at PittsburghL  6-10 37-62
9/30at NY MetsL  1-2 37-63
10/2at PhiladelphiaL  7-9 37-64
10/3at PhiladelphiaW  8-4 38-64
10/4at PhiladelphiaL  1-2 38-65