The season was impacted by the ongoing COVID-19 pandemic; the most prominent changes were the cancellation of all preseason games and the postponement and/or rescheduling of multiple games due to positive COVID-19 tests among players and staff. Despite the changes, all 256 regular season games were played within the original 17-week span, with no cancellations.
2020 Regular Season Results | |||||||||||||||||||
| Date | Opponent | Result | Score | OT | Record | ||||||||||||||
| 9/10 | at Kansas City | L | 20-34 | 0-1 | |||||||||||||||
| 9/20 | vs Baltimore | L | 16-33 | 0-2 | |||||||||||||||
| 9/27 | at Pittsburgh | L | 21-28 | 0-3 | |||||||||||||||
| 10/4 | vs Minnesota | L | 23-31 | 0-4 | |||||||||||||||
| 10/11 | vs Jacksonville | W | 30-14 | 1-4 | |||||||||||||||
| 10/18 | at Tennessee | L | 36-42 | 1-5 | |||||||||||||||
| 10/25 | vs Green Bay | L | 20-35 | 1-6 | |||||||||||||||
| 11/8 | at Jacksonville | W | 27-25 | 2-6 | |||||||||||||||
| 11/15 | at Cleveland | L | 7-10 | 2-7 | |||||||||||||||
| 11/22 | vs New England | W | 27-20 | 3-7 | |||||||||||||||
| 11/26 | at Detroit | W | 41-25 | 4-7 | |||||||||||||||
| 12/6 | vs Indianapolis | L | 20-26 | 4-8 | |||||||||||||||
| 12/13 | at Chicago | L | 7-36 | 4-9 | |||||||||||||||
| 12/20 | at Indianapolis | L | 20-27 | 4-10 | |||||||||||||||
| 12/27 | vs Cincinnati | L | 31-37 | 4-11 | |||||||||||||||
| 1/3 | vs Tennessee | L | 38-41 | 4-12 | |||||||||||||||