Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/11at ClevelandW  5-3 1-0
4/12at ClevelandW  6-1 2-0
4/14at Chi. White SoxL  3-9 2-1
4/15at Chi. White SoxL  4-5 2-2
4/16vs ClevelandL  0-1 2-3
4/18vs ClevelandL  0-5 2-4
4/20at TorontoW  5-4
12
3-4
4/21at TorontoW  6-2 4-4
4/22at TorontoW  8-1 5-4
4/24vs Kansas CityW  6-1 6-4
4/25vs Kansas CityL  2-4 6-5
4/26vs Kansas CityW  11-1 7-5
4/27vs TorontoW  4-3
12
8-5
4/28vs TorontoL  2-6 8-6
4/29vs TorontoL  0-5
14
8-7
4/30at CaliforniaW  12-1 9-7
5/1at CaliforniaL  4-8 9-8
5/2at CaliforniaW  8-5 10-8
5/3at CaliforniaW  4-3 11-8
5/4at SeattleW  9-5 12-8
5/5at SeattleW  4-1 13-8
5/6at SeattleL  1-12 13-9
5/7at SeattleL  1-4 13-10
5/8at OaklandL  0-2 13-11
5/9at OaklandL  5-6
12
13-12
5/10at OaklandW  13-5 14-12
5/12vs CaliforniaL  0-4 14-13
5/13vs CaliforniaL  3-6 14-14
5/14vs CaliforniaL  1-9 14-15
5/15vs OaklandW  3-0 15-15
5/16vs OaklandW  6-5 16-15
5/17vs OaklandW  6-2 17-15
5/19vs MinnesotaW  4-3 18-15
5/20vs MinnesotaW  6-1 19-15
5/21vs MinnesotaW  8-2 20-15
5/22vs BostonL  3-7 20-16
5/23vs BostonL  1-8 20-17
5/24vs BostonW  2-1
14
21-17
5/24vs BostonW  10-7 22-17
5/25vs DetroitL  3-12 22-18
5/26vs DetroitW  7-3 23-18
5/27vs DetroitW  5-1 24-18
5/28vs DetroitW  7-1 25-18
5/29at BostonW  5-4 26-18
5/30at BostonL  6-7
10
26-19
5/31at BostonW  5-2 27-19
6/1at DetroitL  3-4
12
27-20
6/2at DetroitW  5-2 28-20
6/3at DetroitL  1-4 28-21
6/5at Kansas CityW  6-2 29-21
6/6at Kansas CityW  4-2 30-21
6/7at Kansas CityL  1-7 30-22
6/8at MinnesotaL  0-1 30-23
6/9at MinnesotaL  1-3 30-24
6/10vs TexasL  5-12 30-25
6/11vs TexasW  6-3 31-25
8/10at ClevelandW  5-2
13
32-25
8/11at ClevelandW  6-1 33-25
8/11at ClevelandW  6-5 34-25
8/12at ClevelandL  4-9 34-26
8/13at ClevelandW  8-5 35-26
8/14at TorontoL  4-5 35-27
8/15at TorontoL  3-4 35-28
8/16at TorontoW  6-2 36-28
8/16at TorontoW  2-0 37-28
8/18at TexasW  3-1 38-28
8/18at TexasL  6-8 38-29
8/19at TexasL  1-4 38-30
8/21vs MinnesotaL  6-7 38-31
8/22vs MinnesotaW  4-3
10
39-31
8/23vs MinnesotaW  8-5 40-31
8/24vs Chi. White SoxW  5-4 41-31
8/25vs Chi. White SoxL  1-5 41-32
8/27vs TexasL  1-5 41-33
8/28vs TexasW  6-3 42-33
8/29vs TexasL  5-8 42-34
8/30vs TexasW  6-2 43-34
8/31at Kansas CityW  5-1 44-34
9/1at Kansas CityL  1-3 44-35
9/2at Kansas CityL  4-5 44-36
9/3at MinnesotaW  4-3 45-36
9/4at MinnesotaW  16-5 46-36
9/5at MinnesotaW  5-3 47-36
9/6at MinnesotaW  8-7
10
48-36
9/7at NY YankeesL  2-4 48-37
9/9at NY YankeesW  5-3 49-37
9/9at NY YankeesL  2-5 49-38
9/10vs Chi. White SoxL  6-12 49-39
9/11vs BaltimoreL  1-2 49-40
9/12vs BaltimoreW  6-3 50-40
9/13vs BaltimoreW  5-0 51-40
9/14vs NY YankeesL  2-10 51-41
9/15vs NY YankeesW  2-1 52-41
9/16vs NY YankeesW  3-2 53-41
9/18at BaltimoreW  5-1 54-41
9/19at BaltimoreW  11-8 55-41
9/20at BaltimoreL  2-8 55-42
9/21at BostonL  3-9 55-43
9/22at BostonW  10-8 56-43
9/23at BostonL  5-11 56-44
9/25at DetroitW  8-6 57-44
9/26at DetroitW  4-3 58-44
9/27at DetroitL  1-2 58-45
9/28vs BostonW  1-0 59-45
9/29vs BostonL  2-7 59-46
9/30vs BostonW  10-5 60-46
10/2vs DetroitW  8-2 61-46
10/3vs DetroitW  2-1 62-46
10/4vs DetroitL  2-3 62-47