Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9at Chi. CubsW  2-0 1-0
4/11at Chi. CubsL  1-3 1-1
4/12at Chi. CubsW  2-1 2-1
4/15vs StL CardinalsW  5-3 3-1
4/16vs StL CardinalsL  1-5 3-2
4/18vs MontrealL  3-5 3-3
4/19vs MontrealW  7-2 4-3
4/19vs MontrealL  3-4 4-4
4/25at MontrealL  2-4 4-5
4/26at MontrealL  4-8 4-6
4/26at MontrealL  6-7 4-7
4/28vs PittsburghL  0-8 4-8
4/29vs PittsburghL  0-10 4-9
4/30vs PittsburghL  4-7 4-10
5/1vs San DiegoL  2-4 4-11
5/2vs San DiegoW  6-2 5-11
5/3vs San DiegoL  1-4 5-12
5/3vs San DiegoW  7-4 6-12
5/5vs San FranciscoL  7-9 6-13
5/6vs San FranciscoL  4-6 6-14
5/7vs San FranciscoW  3-2 7-14
5/8vs LA DodgersL  0-1 7-15
5/9vs LA DodgersW  7-4 8-15
5/10vs LA DodgersL  3-5 8-16
5/12at San DiegoL  0-3 8-17
5/13at San DiegoL  0-5 8-18
5/14at San DiegoL  6-10 8-19
5/15at LA DodgersL  5-6 8-20
5/16at LA DodgersL  0-9 8-21
5/17at LA DodgersL  1-6 8-22
5/18at San FranciscoL  1-3 8-23
5/19at San FranciscoL  1-4 8-24
5/20at San FranciscoW  4-3
10
9-24
5/22at StL CardinalsW  9-3 10-24
5/23at StL CardinalsL  2-8 10-25
5/24at StL CardinalsW  3-1
10
11-25
5/25vs PhiladelphiaW  13-3 12-25
5/26vs PhiladelphiaL  5-7 12-26
5/27vs PhiladelphiaW  3-1 13-26
5/29vs Chi. CubsW  6-1 14-26
5/30vs Chi. CubsL  3-10 14-27
5/31vs Chi. CubsW  3-2 15-27
6/1at PhiladelphiaL  4-5 15-28
6/2at PhiladelphiaL  7-9 15-29
6/3at PhiladelphiaW  6-2 16-29
6/5at HoustonL  0-3 16-30
6/6at HoustonL  2-6 16-31
6/7at HoustonW  3-1 17-31
6/9vs CincinnatiL  4-8 17-32
6/10vs CincinnatiL  0-2 17-33
6/11vs CincinnatiL  2-5 17-34
8/10at Chi. CubsW  7-5
13
18-34
8/11at Chi. CubsW  4-2 19-34
8/12at Chi. CubsW  7-4
10
20-34
8/13at Chi. CubsL  1-6 20-35
8/14vs PhiladelphiaL  4-8 20-36
8/15vs PhiladelphiaW  3-1 21-36
8/16vs PhiladelphiaW  5-2 22-36
8/18at AtlantaW  4-0 23-36
8/19at AtlantaL  2-5 23-37
8/20at AtlantaL  4-6 23-38
8/21at CincinnatiL  0-2 23-39
8/22at CincinnatiW  7-4 24-39
8/23at CincinnatiW  3-2
10
25-39
8/24at CincinnatiL  0-2 25-40
8/25vs HoustonW  2-1 26-40
8/26vs HoustonL  3-9 26-41
8/27vs HoustonW  3-2 27-41
8/28vs CincinnatiL  2-5 27-42
8/28vs CincinnatiW  3-2 28-42
8/30vs CincinnatiL  3-6 28-43
8/31at HoustonL  1-6 28-44
9/1at HoustonL  2-3 28-45
9/2at HoustonL  0-8 28-46
9/4vs AtlantaW  4-1 29-46
9/5vs AtlantaW  4-2 30-46
9/6vs AtlantaL  2-5 30-47
9/7at PittsburghL  1-2 30-48
9/7at PittsburghL  4-5 30-49
9/8at PittsburghW  3-1 31-49
9/9at PittsburghW  5-3 32-49
9/11at StL CardinalsL  2-4 32-50
9/12at StL CardinalsL  2-4
13
32-51
9/13at StL CardinalsL  2-4 32-52
9/16vs PhiladelphiaW  5-4 33-52
9/16vs PhiladelphiaL  1-3 33-53
9/17vs PhiladelphiaL  2-3 33-54
9/18vs StL CardinalsW  8-1 34-54
9/19vs StL CardinalsW  6-2 35-54
9/20vs StL CardinalsW  7-6 36-54
9/21vs PittsburghW  4-3
13
37-54
9/22vs PittsburghL  3-5 37-55
9/23at Chi. CubsL  1-2 37-56
9/24at Chi. CubsL  9-10 37-57
9/25at MontrealL  3-6 37-58
9/26at MontrealL  2-4 37-59
9/27at MontrealW  2-1 38-59
9/28at PhiladelphiaL  4-12 38-60
9/29at PhiladelphiaW  7-0 39-60
9/30vs Chi. CubsW  2-1 40-60
10/2vs MontrealL  0-3 40-61
10/3vs MontrealL  4-5 40-62
10/4vs MontrealW  2-1 41-62