Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9vs TexasW  10-3 1-0
4/11vs TexasW  5-1 2-0
4/12vs TexasL  4-6 2-1
4/13at TorontoL  1-5 2-2
4/15at TorontoW  6-3 3-2
4/17at TexasW  2-1 4-2
4/18at TexasL  4-6 4-3
4/19at TexasL  0-4 4-4
4/20vs DetroitW  6-2 5-4
4/21vs DetroitW  2-0 6-4
4/22vs DetroitW  7-2 7-4
4/24vs TorontoW  4-2 8-4
4/25vs TorontoL  2-7 8-5
4/26vs TorontoL  1-2 8-6
4/27at DetroitW  3-1 9-6
4/28at DetroitW  4-1 10-6
4/29at DetroitW  3-2 11-6
5/1at OaklandL  6-8 11-7
5/2at OaklandL  3-6 11-8
5/3at OaklandW  3-2
10
12-8
5/3at OaklandW  2-0 13-8
5/4at CaliforniaW  4-2 14-8
5/5at CaliforniaL  2-6 14-9
5/6at CaliforniaW  5-2 15-9
5/7at CaliforniaL  1-2 15-10
5/8at SeattleL  2-3 15-11
5/9at SeattleL  5-6 15-12
5/10at SeattleW  5-2 16-12
5/12vs OaklandW  4-1 17-12
5/13vs OaklandL  4-5 17-13
5/14vs OaklandW  9-5 18-13
5/16vs SeattleW  7-5 19-13
5/17vs SeattleL  0-1 19-14
5/18vs Kansas CityW  2-1 20-14
5/19vs Kansas CityW  6-5 21-14
5/20vs Kansas CityW  5-4
11
22-14
5/22vs ClevelandL  3-7 22-15
5/23vs ClevelandW  3-2 23-15
5/24vs ClevelandL  5-12 23-16
5/25at BaltimoreL  1-10 23-17
5/26at BaltimoreL  4-6 23-18
5/27at BaltimoreL  5-6 23-19
5/29at ClevelandW  5-2 24-19
5/30at ClevelandW  1-0 25-19
5/31at ClevelandL  2-7 25-20
6/1at ClevelandW  5-3 26-20
6/2vs BaltimoreW  5-3
11
27-20
6/3vs BaltimoreW  2-0
11
28-20
6/4vs BaltimoreW  12-3 29-20
6/5vs Chi. White SoxW  6-5
12
30-20
6/6vs Chi. White SoxW  2-0 31-20
6/7vs Chi. White SoxW  3-1 32-20
6/8at Kansas CityW  8-3 33-20
6/9at Kansas CityW  8-5 34-20
6/10at Chi. White SoxL  5-6 34-21
6/11at Chi. White SoxL  2-3 34-22
8/10vs TexasW  2-0 35-22
8/11vs TexasL  0-1 35-23
8/12vs TexasW  5-4 36-23
8/13at DetroitW  3-0 37-23
8/14at DetroitL  0-1 37-24
8/15at DetroitL  5-8 37-25
8/16at DetroitL  4-5 37-26
8/17vs Chi. White SoxL  1-4 37-27
8/18vs Chi. White SoxW  4-0 38-27
8/19vs Chi. White SoxL  5-6 38-28
8/21vs Kansas CityL  0-4 38-29
8/22vs Kansas CityW  5-0 39-29
8/23vs Kansas CityW  8-0 40-29
8/24vs MinnesotaL  2-3
12
40-30
8/25vs MinnesotaL  0-3 40-31
8/26vs MinnesotaW  3-2 41-31
8/27at Chi. White SoxL  1-3 41-32
8/28at Chi. White SoxW  6-1 42-32
8/29at Chi. White SoxW  12-2 43-32
8/30at Chi. White SoxW  5-1 44-32
8/31at MinnesotaW  7-0 45-32
9/1at MinnesotaW  11-6 46-32
9/2at MinnesotaL  3-4 46-33
9/3at Kansas CityL  2-3 46-34
9/4at Kansas CityW  4-0 47-34
9/5at Kansas CityW  2-1 48-34
9/6at Kansas CityW  6-1 49-34
9/7vs MilwaukeeW  4-2 50-34
9/9vs MilwaukeeL  3-5 50-35
9/9vs MilwaukeeW  5-2 51-35
9/11vs BostonW  4-1 52-35
9/12vs BostonL  1-2 52-36
9/13vs BostonW  10-6 53-36
9/14at MilwaukeeW  10-2 54-36
9/15at MilwaukeeL  1-2 54-37
9/16at MilwaukeeL  2-3 54-38
9/18at BostonW  6-4 55-38
9/19at BostonL  5-8 55-39
9/20at BostonL  1-4 55-40
9/21vs ClevelandL  0-5 55-41
9/22vs ClevelandL  4-6 55-42
9/23vs ClevelandW  6-1 56-42
9/24vs BaltimoreL  1-5 56-43
9/25vs BaltimoreL  0-1 56-44
9/26vs BaltimoreW  6-4 57-44
9/27vs BaltimoreW  5-2 58-44
9/28at ClevelandL  2-6 58-45
9/29at ClevelandL  2-3 58-46
10/2at BaltimoreW  9-0 59-46
10/3at BaltimoreL  0-3 59-47
10/4at BaltimoreL  2-5 59-48