Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9at DetroitL  2-6 0-1
4/11at DetroitL  2-6 0-2
4/12at DetroitW  6-2 1-2
4/13vs NY YankeesW  5-1 2-2
4/15vs NY YankeesL  3-6 2-3
4/16vs DetroitL  0-2 2-4
4/17vs DetroitL  5-8 2-5
4/18vs DetroitL  3-4 2-6
4/19vs DetroitW  9-1 3-6
4/20vs MilwaukeeL  4-5
12
3-7
4/21vs MilwaukeeL  2-6 3-8
4/22vs MilwaukeeL  1-8 3-9
4/24at NY YankeesL  2-4 3-10
4/25at NY YankeesW  7-2 4-10
4/26at NY YankeesW  2-1 5-10
4/27at MilwaukeeL  3-4
12
5-11
4/28at MilwaukeeW  6-2 6-11
4/29at MilwaukeeW  5-0
14
7-11
4/30at BaltimoreL  0-4 7-12
5/2at BaltimoreL  3-4 7-13
5/2at BaltimoreL  3-8 7-14
5/3at BaltimoreW  4-2 8-14
5/6vs ClevelandL  1-4 8-15
5/7vs ClevelandW  6-2 9-15
5/8vs BostonL  2-4 9-16
5/9vs BostonL  3-10 9-17
5/10vs BostonL  5-9
10
9-18
5/11vs BostonL  6-7 9-19
5/12vs BaltimoreW  5-2 10-19
5/13vs BaltimoreL  0-4 10-20
5/14vs BaltimoreL  0-10 10-21
5/15at ClevelandL  0-3 10-22
5/16at ClevelandW  4-1 11-22
5/17at ClevelandL  0-1 11-23
5/17at ClevelandL  1-2
10
11-24
5/18vs Chi. White SoxL  2-7 11-25
5/19vs Chi. White SoxW  9-5 12-25
5/20vs Chi. White SoxL  5-6 12-26
5/22at OaklandL  2-6 12-27
5/23at OaklandL  2-3
15
12-28
5/24at OaklandL  0-5 12-29
5/24at OaklandL  5-6
12
12-30
5/25at CaliforniaL  1-2 12-31
5/26at CaliforniaW  8-4 13-31
5/27at CaliforniaW  3-1 14-31
5/29vs OaklandW  6-3 15-31
5/30vs OaklandW  6-5 16-31
5/31vs OaklandL  5-6 16-32
6/1vs CaliforniaL  0-3 16-33
6/2vs CaliforniaL  0-3 16-34
6/3vs CaliforniaL  6-17 16-35
6/5at TexasL  4-5
12
16-36
6/6at TexasL  1-4 16-37
6/7at TexasL  0-9 16-38
6/8at Chi. White SoxL  2-6 16-39
6/9at Chi. White SoxL  0-3 16-40
6/10vs Kansas CityL  4-7 16-41
6/11vs Kansas CityL  5-10 16-42
8/10at DetroitL  3-4 16-43
8/11at DetroitW  6-4 17-43
8/12at DetroitW  4-3 18-43
8/14vs MilwaukeeW  5-4 19-43
8/15vs MilwaukeeW  4-3 20-43
8/16vs MilwaukeeL  2-6 20-44
8/16vs MilwaukeeL  0-2 20-45
8/17at Kansas CityL  3-5 20-46
8/18at Kansas CityW  5-3 21-46
8/19at Kansas CityW  9-4 22-46
8/21vs Chi. White SoxW  5-4 23-46
8/22vs Chi. White SoxL  0-8 23-47
8/23vs Chi. White SoxL  2-13 23-48
8/24vs TexasL  0-3 23-49
8/25vs TexasL  1-6 23-50
8/27vs Kansas CityL  5-11 23-51
8/28vs Kansas CityW  4-3 24-51
8/29vs Kansas CityL  0-2 24-52
8/31at TexasW  3-0 25-52
9/1at TexasW  9-3 26-52
9/2at TexasL  1-4 26-53
9/3at Chi. White SoxL  3-4 26-54
9/4at Chi. White SoxW  6-2 27-54
9/5at Chi. White SoxW  3-1 28-54
9/6at Chi. White SoxW  3-2 29-54
9/7at MinnesotaL  0-4 29-55
9/8at MinnesotaL  0-1 29-56
9/9at MinnesotaL  1-3 29-57
9/10vs SeattleW  2-0 30-57
9/11vs SeattleL  1-8 30-58
9/12vs SeattleW  3-0 31-58
9/14vs MinnesotaL  3-6 31-59
9/15vs MinnesotaW  4-2 32-59
9/16vs MinnesotaL  2-5 32-60
9/18vs CaliforniaW  5-1 33-60
9/19vs CaliforniaW  6-4 34-60
9/20vs CaliforniaW  6-3 35-60
9/22vs OaklandL  2-4 35-61
9/22vs OaklandL  2-3
13
35-62
9/23vs OaklandL  0-6 35-63
9/25at CaliforniaL  5-11 35-64
9/26at CaliforniaL  3-6 35-65
9/27at CaliforniaW  4-3 36-65
9/29at OaklandL  1-5 36-66
9/30at OaklandL  0-3 36-67
10/2at SeattleL  3-8 36-68
10/3at SeattleW  4-3 37-68
10/4at SeattleL  0-2 37-69