The 2007 NFL season was the 88th regular season of the National Football League.
Regular-season play was held from September 6 to December 30. The campaign kicked off with the defending Super Bowl XLI champion Indianapolis Colts defeating the New Orleans Saints 41–10 in the NFL Kickoff Game.
The New England Patriots became the first team to complete the regular season undefeated since the league expanded to a 16-game regular season in 1978. Four weeks after the playoffs began on January 5, 2008, the Patriots' bid for a perfect season was dashed when they lost to the New York Giants in Super Bowl XLII, the league championship game at University of Phoenix Stadium in Glendale, Arizona on February 3, by a score of 17–14.