Crane began his professional career in 1884 with the Philadelphia Quakers of the National League. He was a reliable pitcher for the team, posting a record of 14-14 in his first season. He also hit for power, leading the team in home runs with five. He continued to be a reliable pitcher for the Quakers, posting a record of 18-17 in 1885 and 16-17 in 1886.
In 1887, Crane was traded to the St. Louis Browns of the American Association. He had a successful season with the Browns, posting a record of 22-14 and leading the team in home runs with nine. He continued to be a reliable pitcher for the Browns, posting a record of 20-17 in 1888 and 19-17 in 1889.
Crane was traded to the Louisville Colonels of the American Association in 1890. He had a successful season with the Colonels, posting a record of 18-14 and leading the team in home runs with seven. He continued to be a reliable pitcher for the Colonels, posting a record of 17-14 in 1891 and 15-14 in 1892.
Crane's last season in professional baseball was 1893 with the Baltimore Orioles of the National League. He had a successful season with the Orioles, posting a record of 17-14 and leading the team in home runs with seven.
Ed Crane was a reliable pitcher and powerful hitter during his professional baseball career. He was a key contributor to several teams in the National League and American Association, and he was known for his strong throwing arm and his ability to hit for power.
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