Born on December 15, 1977, in Portland, Oregon, Glendon Rusch developed a love for baseball at an early age. His journey in the sport began in high school, where he showcased his talents as a pitcher. After a standout career at Jesuit High School, he was selected by the New York Mets in the 1996 MLB Draft.

Rusch made his Major League debut with the Mets in 1997, stepping onto the mound for the first time in a game against the Atlanta Braves. Although his initial stint in New York was brief, it marked the beginning of a career that would span over a decade and include multiple teams. Following his time with the Mets, he was traded to the Chicago Cubs, where he continued to develop his skills as a pitcher.

In 2002, Rusch found himself with the Milwaukee Brewers, where he began to establish himself as a reliable left-handed pitcher. His ability to adapt to different roles, whether as a starter or a reliever, allowed him to find opportunities across various teams. Rusch's tenure with the Brewers was marked by solid performances, and he became known for his competitive spirit on the mound.

The Chicago Cubs came calling again in 2003, and Rusch returned to the Windy City. During this period, he had some of his most productive seasons, including a notable year in 2004 when he recorded a career-high 10 wins. His contributions to the Cubs were appreciated by fans and teammates alike, as he consistently delivered when called upon.

In 2005, Rusch faced challenges with injuries that limited his appearances. However, he persevered and continued to work hard to return to form. His resilience paid off, and he found himself back in the rotation, showcasing his ability to bounce back from adversity.

The Kansas City Royals signed Rusch in 2007, where he continued to pitch effectively. His experience and knowledge of the game made him a valuable asset to the teams he played for. Rusch's career took him to the San Diego Padres in 2008, where he continued to demonstrate his skills on the mound.

Rusch's final season in Major League Baseball came in 2009 with the Seattle Mariners. After a decade of competing at the highest level, he decided to retire from professional baseball. Throughout his career, Rusch was known for his work ethic and his ability to adapt to various roles within a pitching staff.