Matt Guerrier's journey in Major League Baseball began when he was drafted by the Chicago White Sox in the 10th round of the 1999 MLB Draft. However, his debut in the major leagues came with the Minnesota Twins, where he became a reliable presence in their bullpen. Guerrier's career spanned over a decade, during which he played for several teams, including the Twins, Los Angeles Dodgers, and Chicago Cubs.

Guerrier's time with the Minnesota Twins was marked by consistency and durability. He joined the Twins in 2004 and quickly established himself as a dependable relief pitcher. Over the years, he became a staple in the Twins' bullpen, known for his ability to handle various relief roles. His performance in the 2007 season was particularly noteworthy, as he appeared in 73 games and posted a 2.35 ERA, showcasing his effectiveness in high-pressure situations.

In 2011, Guerrier signed a three-year contract with the Los Angeles Dodgers. His tenure with the Dodgers saw him continue to be a steady arm out of the bullpen, although he faced some challenges with injuries. Despite these setbacks, Guerrier maintained his reputation as a reliable reliever, contributing to the Dodgers' pitching staff with his experience and skill.

Guerrier's career also included a brief stint with the Chicago Cubs in 2014. Although his time with the Cubs was short-lived, it added another chapter to his professional journey. Throughout his career, Guerrier was known for his work ethic and ability to adapt to different roles within the bullpen, whether as a middle reliever or setup man.