The Cincinnati Gardens' first event was an exhibition hockey game. It has been the home of six league championship hockey teams, and most recently was the home of the Cincinnati Mighty Ducks of the American Hockey League. It also has been host to numerous other sporting events, concerts, stage shows, circuses, and political rallies. The Gardens' final tenants were the Cincinnati Rollergirls of the Women's Flat Track Derby Association and the Cincinnati Thunder of the North American 3 Hockey League.
In 2013, the Robinson family, which had owned the Gardens since 1979, put the arena up for sale. The family-controlled company, Kenko Corporation, no longer considered the arena a core asset. On June 16, 2016, the Port of Greater Cincinnati Development Authority approved a contract to acquire the property for $1.75 million from the Robinson family, which intended to repurpose the 19-acre (7.7 ha) site for future light manufacturing. Demolition took place in March 2018.