The Renaissance Theatre Building, as it was originally named, opened January 1921. It was built and owned, until 1931, by African Americans. It was known as the "Rennie" and was an upscale reception hall. The "Renny" held prize fights, dance marathons, film screenings, concerts, and stage acts. It was also a meeting place for social clubs and political organizations in Harlem. They gathered to dance the popular dances at the time, the Charleston, Lindy Hop, and Black Bottom, to live music performed by well known jazz musicians. Jazz artists such as Louis Armstrong, Fletcher Henderson, Duke Ellington, Count Basie, Cab Calloway, Lionel Hampton, Cootie Williams, Bessie Smith, Lena Horne, Billie Holiday and Ella Fitzgerald performed at the "Renny". In the 1920s the Renaissance Ballroom was known as a "Black Mecca". It hosted Joe Louis fights. The ballroom was on the second floor of the entertainment complex.

The "Renny" was a significant entertainment center during the Harlem Renaissance, and the New Negro Movement in Harlem. When African American culture and art flourished. historically important structure helped usher in the decade-long period of African American cultural and artistic flourishing, which at the time was known as the New Negro Movement. William H. Roach from Antigua, Cleophus Charity and Joseph H. Sweeney from Montserrat were the founding builders of the Renaissance Complex. They were members of Marcus Garvey’s Universal Negro Improvement Association (UNIA).

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