Due to the COVID-19 pandemic, the regular season was reduced to 56 games and began on January 13, 2021. Due to cross-border travel restrictions imposed by Canada, the league temporarily realigned for this season, putting all seven Canadian teams into one division.
2021 Regular Season Results | |||||||||||||||||||
| Date | Opponent | Result | Score | OT | Record | ||||||||||||||
| 1/14 | at New Jersey | W | 3-2 SO | SO | 1-0 | ||||||||||||||
| 1/16 | at New Jersey | OTL | 1-2 OT | OT | 1-0-1 | ||||||||||||||
| 1/18 | at NY Islanders | L | 0-1 | 1-1-1 | |||||||||||||||
| 1/21 | vs Philadelphia | W | 5-4 SO | SO | 2-1-1 | ||||||||||||||
| 1/23 | vs Philadelphia | W | 6-1 | 3-1-1 | |||||||||||||||
| 1/26 | vs Pittsburgh | W | 3-2 OT | OT | 4-1-1 | ||||||||||||||
| 1/28 | vs Pittsburgh | W | 4-1 | 5-1-1 | |||||||||||||||
| 1/30 | at Washington | OTL | 3-4 OT | OT | 5-1-2 | ||||||||||||||
| 2/1 | at Washington | W | 5-3 | 6-1-2 | |||||||||||||||
| 2/3 | at Philadelphia | W | 4-3 OT | OT | 7-1-2 | ||||||||||||||
| 2/5 | at Philadelphia | W | 2-1 | 8-1-2 | |||||||||||||||
| 2/10 | at NY Rangers | W | 3-2 OT | OT | 9-1-2 | ||||||||||||||
| 2/12 | at NY Rangers | W | 1-0 | 10-1-2 | |||||||||||||||
| 2/13 | at NY Islanders | L | 2-4 | 10-2-2 | |||||||||||||||
| 2/18 | vs New Jersey | L | 2-3 | 10-3-2 | |||||||||||||||
| 2/21 | vs Philadelphia | W | 7-3 | 11-3-2 | |||||||||||||||
| 2/25 | at NY Islanders | L | 2-7 | 11-4-2 | |||||||||||||||
| 2/26 | at NY Rangers | L | 2-6 | 11-5-2 | |||||||||||||||
| 2/28 | at NY Rangers | W | 4-1 | 12-5-2 | |||||||||||||||
| 3/3 | vs Washington | OTL | 1-2 SO | SO | 12-5-3 | ||||||||||||||
| 3/5 | vs Washington | W | 5-1 | 13-5-3 | |||||||||||||||
| 3/7 | vs New Jersey | L | 0-1 | 13-6-3 | |||||||||||||||
| 3/9 | at NY Islanders | OTL | 1-2 SO | SO | 13-6-4 | ||||||||||||||
| 3/11 | vs NY Rangers | W | 4-0 | 14-6-4 | |||||||||||||||
| 3/13 | vs NY Rangers | L | 0-4 | 14-7-4 | |||||||||||||||
| 3/15 | at Pittsburgh | L | 1-4 | 14-8-4 | |||||||||||||||
| 3/16 | at Pittsburgh | W | 2-1 | 15-8-4 | |||||||||||||||
| 3/18 | at Buffalo | W | 4-1 | 16-8-4 | |||||||||||||||
| 3/25 | vs NY Islanders | OTL | 3-4 OT | OT | 16-8-5 | ||||||||||||||
| 3/27 | vs Buffalo | W | 3-2 | 17-8-5 | |||||||||||||||
| 3/28 | vs New Jersey | L | 0-1 | 17-9-5 | |||||||||||||||
| 3/30 | vs New Jersey | W | 5-4 SO | SO | 18-9-5 | ||||||||||||||
| 4/1 | vs Pittsburgh | L | 1-4 | 18-10-5 | |||||||||||||||
| 4/3 | vs Pittsburgh | W | 7-5 | 19-10-5 | |||||||||||||||
| 4/5 | vs Philadelphia | OTL | 2-3 OT | OT | 19-10-6 | ||||||||||||||
| 4/6 | at Philadelphia | W | 4-2 | 20-10-6 | |||||||||||||||
| 4/8 | at Washington | W | 4-2 | 21-10-6 | |||||||||||||||
| 4/10 | at Philadelphia | L | 2-3 | 21-11-6 | |||||||||||||||
| 4/11 | vs Washington | L | 1-8 | 21-12-6 | |||||||||||||||
| 4/13 | vs Buffalo | W | 3-2 SO | SO | 22-12-6 | ||||||||||||||
| 4/15 | vs NY Islanders | W | 4-1 | 23-12-6 | |||||||||||||||
| 4/16 | vs NY Islanders | W | 3-0 | 24-12-6 | |||||||||||||||
| 4/18 | vs Washington | W | 6-3 | 25-12-6 | |||||||||||||||
| 4/20 | at Buffalo | W | 2-0 | 26-12-6 | |||||||||||||||
| 4/22 | at Buffalo | W | 5-1 | 27-12-6 | |||||||||||||||
| 4/23 | at Buffalo | L | 4-6 | 27-13-6 | |||||||||||||||
| 4/25 | at Pittsburgh | L | 0-1 | 27-14-6 | |||||||||||||||
| 4/27 | at Pittsburgh | W | 3-1 | 28-14-6 | |||||||||||||||
| 4/29 | vs Buffalo | W | 5-2 | 29-14-6 | |||||||||||||||
| 5/1 | vs Buffalo | W | 6-2 | 30-14-6 | |||||||||||||||
| 5/3 | at New Jersey | W | 3-0 | 31-14-6 | |||||||||||||||
| 5/4 | at New Jersey | OTL | 3-4 OT | OT | 31-14-7 | ||||||||||||||
| 5/6 | vs NY Rangers | W | 4-0 | 32-14-7 | |||||||||||||||
| 5/8 | vs NY Rangers | L | 4-5 | 32-15-7 | |||||||||||||||
| 5/10 | vs NY Islanders | W | 3-2 OT | OT | 33-15-7 | ||||||||||||||
| 5/11 | at Washington | L | 1-2 | 33-16-7 | |||||||||||||||