In 1925, Detroit fielded its second NFL franchise, the Detroit Panthers. The team was organized by future Hall of Famer, Jimmy Conzelman. Conzelman was a quarterback who had recently played with the Decatur Staleys, Rock Island Independents and the Milwaukee Badgers. Conzelman served as the team's owner, coach, and starting quarterback. The Panthers started the season 8–1. However, a 6–3 upset loss to the Independents on Thanksgiving Day knocked them out of first place and they ended the season in third.
The Panthers hoped to build on their 1925 season, but they opened the 1926 season with an 0–3 record. After rallying to a 4–0–2 record in their next six games, they lost their last three. Conzelman gave up the franchise and joined the Providence Steam Roller as player-coach.