The season was extended one week, each team playing 17 games with one bye-week across the 18-week schedule.

2021 Regular Season Results

Date    OpponentResultScoreRecord
9/12at New OrleansL  3-38 0-1
9/20vs DetroitW  35-17 1-1
9/26at San FranciscoW  30-28 2-1
10/3vs PittsburghW  27-17 3-1
10/10at CincinnatiW  25-22 4-1
10/17at ChicagoW  24-14 5-1
10/24vs WashingtonW  24-10 6-1
10/28at ArizonaW  24-21 7-1
11/7at Kansas CityL  7-13 7-2
11/14vs SeattleW  17-0 8-2
11/21at MinnesotaL  31-34 8-3
11/28vs LA RamsW  36-28 9-3
12/12vs ChicagoW  45-30 10-3
12/19at BaltimoreW  31-30 11-3
12/25vs ClevelandW  24-22 12-3
1/2vs MinnesotaW  37-10 13-3
1/9at DetroitL  30-37 13-4