The Harrisburg Senators were an American basketball team based in Harrisburg, Pennsylvania, that was originally formed as a member of the American Basketball League, where it played for one season.
From 1947 to 1951, the Harrisburg Senators played in the Eastern Professional Basketball League. Without a true basketball arena available at the time, the Senators split their games between the Madrid Palestra and the Zembo Mosque, two buildings that were large enough to hold a court and bleachers. During that time, the team's leading scorer was Joe Cackovic. The franchise reached the EPBL finals in both the 1948–49 and 1949-50 seasons.