The season was impacted by the ongoing COVID-19 pandemic; the most prominent changes were the cancellation of all preseason games and the postponement and/or rescheduling of multiple games due to positive COVID-19 tests among players and staff. Despite the changes, all 256 regular season games were played within the original 17-week span, with no cancellations.
2020 Regular Season Results | |||||||||||||||||||
| Date | Opponent | Result | Score | OT | Record | ||||||||||||||
| 9/13 | vs Tampa Bay | W | 34-23 | 1-0 | |||||||||||||||
| 9/21 | at Las Vegas | L | 24-34 | 1-1 | |||||||||||||||
| 9/27 | vs Green Bay | L | 30-37 | 1-2 | |||||||||||||||
| 10/4 | at Detroit | W | 35-29 | 2-2 | |||||||||||||||
| 10/12 | vs LA Chargers | W | 30-27 | 3-2 | |||||||||||||||
| 10/25 | vs Carolina | W | 27-24 | 4-2 | |||||||||||||||
| 11/1 | at Chicago | W | 26-23 | 5-2 | |||||||||||||||
| 11/8 | at Tampa Bay | W | 38-3 | 6-2 | |||||||||||||||
| 11/15 | vs San Francisco | W | 27-13 | 7-2 | |||||||||||||||
| 11/22 | vs Atlanta | W | 24-9 | 8-2 | |||||||||||||||
| 11/29 | at Denver | W | 31-3 | 9-2 | |||||||||||||||
| 12/6 | at Atlanta | W | 21-16 | 10-2 | |||||||||||||||
| 12/13 | at Philadelphia | L | 21-24 | 10-3 | |||||||||||||||
| 12/20 | vs Kansas City | L | 29-32 | 10-4 | |||||||||||||||
| 12/25 | vs Minnesota | W | 52-33 | 11-4 | |||||||||||||||
| 1/3 | at Carolina | W | 33-7 | 12-4 | |||||||||||||||