Following the collapse of the American Association, the National League holds its first meeting. They decide to split 1892 into two halves, with the winners to meet in a championship series following the regular season.
* June 6 – Benjamin Harrison becomes the first president to attend a game while in office when he watched the Cincinnati Reds defeat the Washington Senators 7-4 in 11 innings.
* July 13 – The final games of the first half are played.
* July 15 – Play resumes for the second half of the season after a one-day break.
* July/August – After Boston cuts some players, it begins the second half slowly and Cleveland takes the lead. Some fans accuse the Boston club of purposely playing poorly "in order to force a playoff at the end of the season", i.e. to generate extra revenue.
* August 6 – Jack Stivetts throws a no-hitter for the Boston Beaneaters in an 11–0 victory over the Brooklyn Grooms.
* August 22 – Louisville Colonels pitcher Ben Sanders hurls a no-hitter in a 6–2 win over the Baltimore Orioles.
* September 21 – John Clarkson of the Cleveland Spiders records his 300th career win.
* October 15 – On the last day of the season, Bumpus Jones of the Cincinnati Reds makes his major league debut with a 7–1 no-hitter against Pittsburgh, becoming the second pitcher to hurl a no-hitter in his first start.
* October 17 – The first-half champion Boston Beaneaters and second-half champion Cleveland Spiders begin a five-game series to determine the overall championship. The first game, pitched by Jack Stivetts for the Beaneaters and Cy Young for the Spiders, ends in a 0–0 tie after 11 innings.
* October 24 – The Boston Beaneaters complete a 5–0 sweep of the Cleveland Spiders to win the championship.
* November 1 – Statistics for the first 154-game season show that Dan Brouthers of the Brooklyn Grooms was the top hitter with a .335 batting average, and Cy Young of the Cleveland Spiders the best pitcher with a 36–11 record and a .766 winning percentage.
* November 17 – National League magnates conclude a four-day meeting in Chicago where they agree to shorten the 1893 schedule to 132 games and drop the double championship concept. They also pledge to continue to reduce player salaries and other team expenses.