The season was impacted by the ongoing COVID-19 pandemic; the most prominent changes were the cancellation of all preseason games and the postponement and/or rescheduling of multiple games due to positive COVID-19 tests among players and staff. Despite the changes, all 256 regular season games were played within the original 17-week span, with no cancellations.
2020 Regular Season Results | |||||||||||||||||||
| Date | Opponent | Result | Score | OT | Record | ||||||||||||||
| 9/13 | at Jacksonville | L | 20-27 | 0-1 | |||||||||||||||
| 9/20 | vs Minnesota | W | 28-11 | 1-1 | |||||||||||||||
| 9/27 | vs NY Jets | W | 36-7 | 2-1 | |||||||||||||||
| 10/4 | at Chicago | W | 19-11 | 3-1 | |||||||||||||||
| 10/11 | at Cleveland | L | 23-32 | 3-2 | |||||||||||||||
| 10/18 | vs Cincinnati | W | 31-27 | 4-2 | |||||||||||||||
| 11/1 | at Detroit | W | 41-21 | 5-2 | |||||||||||||||
| 11/8 | vs Baltimore | L | 10-24 | 5-3 | |||||||||||||||
| 11/12 | at Tennessee | W | 34-17 | 6-3 | |||||||||||||||
| 11/22 | vs Green Bay | W | 34-31 | 7-3 | |||||||||||||||
| 11/29 | vs Tennessee | L | 26-45 | 7-4 | |||||||||||||||
| 12/6 | at Houston | W | 26-20 | 8-4 | |||||||||||||||
| 12/13 | at Las Vegas | W | 44-27 | 9-4 | |||||||||||||||
| 12/20 | vs Houston | W | 27-20 | 10-4 | |||||||||||||||
| 12/27 | at Pittsburgh | L | 24-28 | 10-5 | |||||||||||||||
| 1/3 | vs Jacksonville | W | 28-14 | 11-5 | |||||||||||||||