The season was extended one week, each team playing 17 games with one bye-week across the 18-week schedule.

2021 Regular Season Results

Date    OpponentResultScoreRecord
9/12at IndianapolisW  28-16 1-0
9/19vs TennesseeL  30-33
OT
1-1
9/26at MinnesotaL  17-30 1-2
10/3at San FranciscoW  28-21 2-2
10/7vs LA RamsL  17-26 2-3
10/17at PittsburghL  20-23
OT
2-4
10/25vs New OrleansL  10-13 2-5
10/31vs JacksonvilleW  31-7 3-5
11/14at Green BayL  0-17 3-6
11/21vs ArizonaL  13-23 3-7
11/29at WashingtonL  15-17 3-8
12/5vs San FranciscoW  30-23 4-8
12/12at HoustonW  33-13 5-8
12/21at LA RamsL  10-20 5-9
12/26vs ChicagoL  24-25 5-10
1/2vs DetroitW  51-29 6-10
1/9at ArizonaW  38-30 7-10