The season was extended one week, each team playing 17 games with one bye-week across the 18-week schedule.

2021 Regular Season Results

Date    OpponentResultScoreRecord
9/12vs ArizonaL  13-38 0-1
9/19at SeattleW  33-30
OT
1-1
9/26vs IndianapolisW  25-16 2-1
10/3at NY JetsL  24-27
OT
2-2
10/10at JacksonvilleW  37-19 3-2
10/18vs BuffaloW  34-31 4-2
10/24vs Kansas CityW  27-3 5-2
10/31at IndianapolisW  34-31
OT
6-2
11/7at LA RamsW  28-16 7-2
11/14vs New OrleansW  23-21 8-2
11/21vs HoustonL  13-22 8-3
11/28at New EnglandL  13-36 8-4
12/12vs JacksonvilleW  20-0 9-4
12/19at PittsburghL  13-19 9-5
12/23vs San FranciscoW  20-17 10-5
1/2vs MiamiW  34-3 11-5
1/9at HoustonW  28-25 12-5