| 2005 | 1 | 1 | Justin Upton | ss | Great Bridge (Chesapeake, VA) | Arizona | |
| 2005 | 1 | 2 | Alex Gordon | 3b | University of Nebraska | Kansas City | |
| 2005 | 1 | 3 | Jeff Clement | c | University of Southern California | Seattle | |
| 2005 | 1 | 4 | Ryan Zimmerman | 3b | University of Virginia | Washington | |
| 2005 | 1 | 5 | Ryan Braun | 3b | University of Miami | Milwaukee | |
| 2005 | 1 | 6 | Ricky Romero | P | Cal State Fullerton | Toronto | |
| 2005 | 1 | 7 | Troy Tulowitzki | ss | Long Beach State University | Colorado | |
| 2005 | 1 | 8 | Wade Townsend | P | Dripping Springs (Dripping Springs,TX) | Tampa Bay | |
| 2005 | 1 | 9 | Mike Pelfrey | P | Wichita State University | NY Mets | |
| 2005 | 1 | 10 | Cameron Maybin | OF | Roberson High School (Asheville, NC) | Detroit | |
| 2005 | 1 | 11 | Andrew McCutchen | OF | Fort Meade (Fort Meade,FL) | Pittsburgh | |
| 2005 | 1 | 12 | Jay Bruce | OF | West Brook (Beaumont, TX) | Cincinnati | |
| 2005 | 1 | 13 | Brandon Snyder | c | Westfield High School (Centreville,VA) | Baltimore | |
| 2005 | 1 | 14 | Trevor Crowe | OF | University of Arizona | Cleveland | |
| 2005 | 1 | 15 | Lance Broadway | P | Texas Christian University | Chi. White Sox | |
| 2005 | 1 | 16 | Chris Volstad | P | Palm Beach Gardens (Palm Beach Gardens,FL) | Florida | |
| 2005 | 1 | 17 | C.J. Henry | ss | Putnam City High School (Oklahoma City, OK) | NY Yankees | |
| 2005 | 1 | 18 | Cesar Carrillo | P | University of Miami | San Diego | |
| 2005 | 1 | 19 | John Mayberry | OF | Stanford University | Texas | |
| 2005 | 1 | 20 | Mark Pawelek | P | Springville (Springville,UT) | Chi. Cubs | |
| 2005 | 1 | 21 | Cliff Pennington | ss | Texas A&M University | Oakland | |
| 2005 | 1 | 22 | Aaron Thompson | P | Second Baptist School (Houston, TX) | Florida | |
| 2005 | 1 | 23 | Jacoby Ellsbury | OF | Oregon State University | Boston | |
| 2005 | 1 | 24 | Brian Bogusevic | P | Tulane University | Houston | |
| 2005 | 1 | 25 | Matt Garza | P | California State University, Fresno | Minnesota | |
| 2005 | 1 | 26 | Craig Hansen | P | St. John's University | Boston | |
| 2005 | 1 | 27 | Joey Devine | P | North Carolina State University | Atlanta | |
| 2005 | 1 | 28 | Colby Rasmus | OF | Russell County (Victorville,CA) | StL Cardinals | |
| 2005 | 1 | 29 | Jacob Marceaux | P | McNeese State University | Florida | |
| 2005 | 1 | 30 | Tyler Greene | ss | Georgia Institute of Technology | StL Cardinals | |
| 2005 | 1 | 31 | Matt Torra | P | University of Massachusetts Amherst | Arizona | |
| 2005 | 1 | 32 | Chaz Roe | P | Lafayette High School (Lexington, KY) | Colorado | |
| 2005 | 1 | 33 | John Drennen | OF | Rancho Bernardo (San Diego, CA) | Cleveland | |
| 2005 | 1 | 34 | Ryan Tucker | P | Temple City High School (Temple City, CA) | Florida | |
| 2005 | 1 | 35 | Cesar Ramos | P | Long Beach State University | San Diego | |
| 2005 | 1 | 36 | Travis Buck | OF | Arizona State University | Oakland | |
| 2005 | 1 | 37 | Trevor Bell | P | Crescenta Valley High School (La Crescenta, CA) | LA Angels | |
| 2005 | 1 | 38 | Eli Iorg | OF | University of Tennessee | Houston | |
| 2005 | 1 | 39 | Henry Sanchez | 1b | Mission Bay High School (San Diego, CA) | Minnesota | |
| 2005 | 1 | 40 | Luke Hochevar | P | University of Tennessee | LA Dodgers | |
| 2005 | 1 | 41 | Beau Jones | P | Destrehan (Destrehan,LA) | Atlanta | |
| 2005 | 1 | 42 | Clay Buchholz | P | Angelina College | Boston | |
| 2005 | 1 | 43 | Mark McCormick | P | Baylor University | StL Cardinals | |
| 2005 | 1 | 44 | Sean West | P | Captain Shreve (Shreveport, LA) | Florida | |
| 2005 | 1 | 45 | Jed Lowrie | 2b | Stanford University | Boston | |
| 2005 | 1 | 46 | Tyler Herron | P | Wellington Christian (Wellington,FL) | StL Cardinals | |
| 2005 | 1 | 47 | Michael Bowden | P | Waubonsie Valley (Aurora, IL) | Boston | |
| 2005 | 1 | 48 | Garret Olson | P | Cal Poly | Baltimore | |
| 2005 | 2 | 49 | Matt Green | P | University of Louisiana-Monroe | Arizona | |
| 2005 | 2 | 50 | Jeff Bianchi | ss | Lampeter Strasburg (Lampeter,PA) | Kansas City | |
| 2005 | 2 | 51 | Ivan De Jesus | ss | Puerto Rico Baseball Academy (Gurabo, Puerto Rico) | LA Dodgers | |
| 2005 | 2 | 52 | Daniel Carte | OF | Winthrop University | Colorado | |
| 2005 | 2 | 53 | Craig Italiano | P | Flower Mound High School (Flower Mound, TX) | Oakland | |
| 2005 | 2 | 54 | Paul Kelly | ss | Flower Mound High School (Flower Mound, TX) | Minnesota | |
| 2005 | 2 | 55 | Zach Simons | P | Everett Community College | Colorado | |
| 2005 | 2 | 56 | Chris Mason | P | University of North Carolina-Greensboro | Tampa Bay | |
| 2005 | 2 | 57 | Jon Egan | c | Cross Creek (Augusta, GA) | Boston | |
| 2005 | 2 | 58 | Ryan Mount | ss | Ayala (Chino Hills,CA) | LA Angels | |
| 2005 | 2 | 59 | Brad Corley | OF | Mississippi State University | Pittsburgh | |
| 2005 | 2 | 60 | Travis Wood | P | Bryant (Bryant, AR) | Cincinnati | |
| 2005 | 2 | 61 | Nolan Reimold | OF | Bowling Green State University | Baltimore | |
| 2005 | 2 | 62 | Stephen Head | 1b | University of Mississippi | Cleveland | |
| 2005 | 2 | 63 | J. Brent Cox | P | University of Texas | NY Yankees | |
| 2005 | 2 | 64 | Kris Harvey | OF | Clemson University | Florida | |
| 2005 | 2 | 65 | Mike Costanzo | 3b | Coastal Carolina University | Philadelphia | |
| 2005 | 2 | 66 | Chase Headley | 3b | University of Tennessee | San Diego | |
| 2005 | 2 | 67 | Johnny Whittleman | 3b | Kingwood High School (Kingwood, TX) | Texas | |
| 2005 | 2 | 68 | Donald Veal | P | Pima Community College | Chi. Cubs | |
| 2005 | 2 | 69 | Jared Lansford | P | St. Francis High School (Mountain View, CA) | Oakland | |
| 2005 | 2 | 70 | Josh Wilson | P | Whitehouse High School (Whitehouse, TX) | StL Cardinals | |
| 2005 | 2 | 71 | P.J. Phillips | ss | Redan High School (Stone Mountain, GA) | LA Angels | |
| 2005 | 2 | 72 | Ralph Henriquez | c | Key West (Key West,FL) | Houston | |
| 2005 | 2 | 73 | Kevin Slowey | P | Winthrop University | Minnesota | |
| 2005 | 2 | 74 | Josh Wall | P | Central Private School (Baker,LA) | LA Dodgers | |
| 2005 | 2 | 75 | Yuniel Escobar | ss | Atlanta | ||
| 2005 | 2 | 76 | Nick Hundley | c | University of Arizona | San Diego | |
| 2005 | 2 | 77 | Jeff Lyman | P | Monte Vista (Danville,CA) | Atlanta | |
| 2005 | 2 | 78 | Nick Webber | P | University of Central Missouri | StL Cardinals | |
| 2005 | 2 | 79 | Brett Hayes | c | University of Nevada | Florida | |
| 2005 | 2 | 80 | Drew Thompson | ss | Jupiter Community High School (Jupiter, FL) | Minnesota | |
| 2005 | 3 | 83 | Micah Owings | P | Tulane University | Arizona | |
| 2005 | 3 | 84 | Brian Duensing | P | University of Nebraska | Minnesota | |
| 2005 | 3 | 89 | Tommy Manzella | SS | Tulane University | Houston | |
| 2005 | 3 | 90 | Chris Robinson | C | University of Illinois | Detroit | |
| 2005 | 3 | 97 | Matt Maloney | P | University of Mississippi | Philadelphia | |
| 2005 | 3 | 98 | Josh Geer | P | Rice University | San Diego | |
| 2005 | 3 | 99 | Taylor Teagarden | C | University of Texas | Texas | |
| 2005 | 3 | 101 | Vincent Mazzaro | P | Rutherford (Rutherford,NJ) | Oakland | |
| 2005 | 3 | 102 | Jensen Lewis | P | Vanderbilt University | Cleveland | |
| 2005 | 3 | 103 | Sean O'Sullivan | P | Valhalla (El Cajon, CA) | LA Angels | |
| 2005 | 3 | 104 | Josh Lindblom | P | Harrison High School (West Lafayette,IN) | Houston | |
| 2005 | 3 | 107 | Jordan Schafer | OF | Winter Haven (Winter Haven, FL) | Atlanta | |
| 2005 | 3 | 109 | Brett Gardner | OF | College of Charleston | NY Yankees | |
| 2005 | 4 | 113 | Justin Thomas | P | Youngstown State University | Seattle | |
| 2005 | 4 | 114 | Justin Maxwell | OF | University of Maryland | Washington | |
| 2005 | 4 | 115 | Matthew Gamel | 3b | Chipola College | Milwaukee | |
| 2005 | 4 | 118 | Jeremy Hellickson | P | Herbert Hoover High School (Des Moines,IA) | Tampa Bay | |
| 2005 | 4 | 120 | Kevin Whelan | P | Texas A&M University | Detroit | |
| 2005 | 4 | 121 | Brent Lillibridge | ss | University of Washington | Pittsburgh | |
| 2005 | 4 | 122 | Sam LeCure | P | University of Texas | Cincinnati | |
| 2005 | 4 | 124 | Jordan Brown | 1b | University of Arizona | Cleveland | |
| 2005 | 4 | 125 | Chris Getz | 2b | University of Michigan | Chi. White Sox | |
| 2005 | 4 | 126 | Gaby Sanchez | c | University of Miami | Florida | |
| 2005 | 4 | 128 | Mike Baxter | OF | Vanderbilt University | San Diego | |
| 2005 | 4 | 133 | Brian Matusz | P | St. Mary's High School (Phoenix, AZ) | LA Angels | |
| 2005 | 4 | 136 | Josh Bell | 3b | Santaluces High School (Lantana, FL) | LA Dodgers | |
| 2005 | 4 | 137 | Mike Broadway | P | Pope County High School (Golconda, IL) | Atlanta | |
| 2005 | 4 | 139 | Lance Pendleton | P | Rice University | NY Yankees | |
| 2005 | 4 | 140 | Bryan Anderson | c | Simi Valley High School (Simi Valley, CA) | StL Cardinals | |
| 2005 | 5 | 149 | Drew Butera | c | University of Central Florida | NY Mets | |
| 2005 | 5 | 150 | Jeff Larish | 1b | Arizona State University | Detroit | |
| 2005 | 5 | 159 | Michael Kirkman | P | Columbia (Lake City,FL) | Texas | |
| 2005 | 5 | 165 | Steven Tolleson | ss | University of South Carolina | Minnesota | |
| 2005 | 5 | 166 | John Meloan | P | University of Arizona | LA Dodgers | |
| 2005 | 5 | 169 | Zach Kroenke | P | University of Nebraska | NY Yankees | |
| 2005 | 5 | 170 | Mitch Boggs | P | University of Georgia | StL Cardinals | |
| 2005 | 6 | 171 | Greg Smith | P | Louisiana State University | Arizona | |
| 2005 | 6 | 173 | Lance Lynn | P | Brownsburg (Brownsburg,IN) | Seattle | |
| 2005 | 6 | 174 | Marco Estrada | P | Long Beach State University | Washington | |
| 2005 | 6 | 180 | Clete Thomas | OF | Auburn University | Detroit | |
| 2005 | 6 | 182 | Jeff Stevens | P | Loyola Marymount University | Cincinnati | |
| 2005 | 6 | 185 | Aaron Cunningham | OF | Everett Community College | Chi. White Sox | |
| 2005 | 6 | 189 | German Duran | 2b | Weatherford College | Texas | |
| 2005 | 6 | 191 | Justin Sellers | ss | Marina High School (Huntington Beach, CA) | Oakland | |
| 2005 | 6 | 193 | Jeremy Moore | OF | North Caddo (Vivian,LA) | LA Angels | |
| 2005 | 6 | 196 | Brent Leach | P | Delta State University | LA Dodgers | |
| 2005 | 6 | 199 | Doug Fister | P | California State University, Fresno | NY Yankees | |
| 2005 | 7 | 205 | Michael Brantley | OF | Fort Pierce Central (Fort Pierce, FL) | Milwaukee | |
| 2005 | 7 | 206 | Robert Ray | P | Texas A&M University | Toronto | |
| 2005 | 7 | 209 | Jon Niese | P | Defiance (Defiance,OH) | NY Mets | |
| 2005 | 7 | 215 | Daniel Cortes | P | Garey High School (Pomona, CA) | Chi. White Sox | |
| 2005 | 7 | 216 | Chris Leroux | P | Winthrop University | Florida | |
| 2005 | 7 | 218 | Will Venable | OF | Princeton University | San Diego | |
| 2005 | 7 | 230 | Nick Stavinoha | OF | Louisiana State University | StL Cardinals | |
| 2005 | 8 | 235 | Jemile Weeks | SS | Lake Brantley (Altamonte Springs,FL) | Milwaukee | |
| 2005 | 8 | 241 | Steve Pearce | 1B | University of South Carolina | Pittsburgh | |
| 2005 | 8 | 245 | Clayton Richard | P | University of Michigan | Chi. White Sox | |
| 2005 | 8 | 246 | Aaron Bates | 1B | North Carolina State University | Florida | |
| 2005 | 8 | 259 | Austin Jackson | OF | Ryan High School (Denton, TX) | NY Yankees | |
| 2005 | 9 | 269 | Bobby Parnell | P | Charleston Southern University | NY Mets | |
| 2005 | 9 | 283 | Bobby Mosebach | P | Hillsborough Community College | LA Angels | |
| 2005 | 10 | 295 | Steve Garrison | P | Hun School (Princeton,NJ) | Milwaukee | |
| 2005 | 10 | 307 | Josh Outman | P | University of Central Missouri | Philadelphia | |
| 2005 | 10 | 313 | Peter Bourjos | OF | Notre Dame Prep (Scottsdale, AZ) | LA Angels | |
| 2005 | 10 | 316 | Trayvon Robinson | OF | Crenshaw High School (Los Angeles, CA) | LA Dodgers | |
| 2005 | 11 | 324 | John Lannan | P | Siena College | Washington | |
| 2005 | 11 | 329 | Luis Martinez | c | Jackson State Community College | NY Mets | |
| 2005 | 11 | 330 | Anthony Claggett | P | University of California-Riverside | Detroit | |
| 2005 | 11 | 332 | Carlos Fisher | P | Lewis-Clark State College | Cincinnati | |
| 2005 | 11 | 337 | Tuffy Gosewisch | c | Arizona State University | Philadelphia | |
| 2005 | 11 | 338 | Josh Tomlin | P | Angelina College | San Diego | |
| 2005 | 12 | 353 | Anthony Varvaro | P | St. John's University | Seattle | |
| 2005 | 12 | 354 | Craig Stammen | P | University of Dayton | Washington | |
| 2005 | 12 | 360 | Matt Joyce | OF | Florida Southern College | Detroit | |
| 2005 | 12 | 362 | Adam Rosales | ss | Western Michigan University | Cincinnati | |
| 2005 | 12 | 363 | John Raynor | OF | University of North Carolina at Wilmington | Baltimore | |
| 2005 | 12 | 367 | Michael Zagurski | P | University of Kansas | Philadelphia | |
| 2005 | 12 | 371 | Jeff Baisley | 3b | University of South Florida | Oakland | |
| 2005 | 12 | 372 | Joseph Martinez | P | Boston College | San Francisco | |
| 2005 | 12 | 375 | Alex Burnett | P | Ocean View (Huntington Beach, CA) | Minnesota | |
| 2005 | 12 | 380 | Daniel McCutchen | P | University of Oklahoma | StL Cardinals | |
| 2005 | 13 | 389 | Josh Thole | c | Mater Dei High School (Breese,IL) | NY Mets | |
| 2005 | 13 | 392 | Logan Ondrusek | P | McLennan Community College | Cincinnati | |
| 2005 | 13 | 399 | Doug Mathis | P | University of Missouri | Texas | |
| 2005 | 13 | 406 | Steven Johnson | P | St. Paul's (Brooklandville,MD) | LA Dodgers | |
| 2005 | 14 | 411 | Rusty Ryal | 3B | University of Oklahoma | Arizona | |
| 2005 | 14 | 420 | Casper Wells | OF | Towson University | Detroit | |
| 2005 | 14 | 436 | Scott Van Slyke | OF | John Burroughs School (Ladue,MO) | LA Dodgers | |
| 2005 | 14 | 438 | Pedro Alvarez | SS | Horace Mann (Bronx, NY) | Boston | |
| 2005 | 15 | 443 | John Holdzkom | P | Rancho Cucamonga (Rancho Cucamonga, CA) | Seattle | |
| 2005 | 15 | 455 | Chris Carter | 3B | Sierra Vista High School (Las Vegas, NV) | Chi. White Sox | |
| 2005 | 15 | 462 | Alex Hinshaw | P | San Diego State University | San Francisco | |
| 2005 | 15 | 467 | Mason Tobin | P | Kentridge (Kent, WA) | Atlanta | |
| 2005 | 16 | 475 | Andrew Bailey | P | Wagner College | Milwaukee | |
| 2005 | 16 | 480 | Michael Holliman | ss | Oral Roberts University | Detroit | |
| 2005 | 16 | 483 | David Hernandez | P | Cosumnes River College | Baltimore | |
| 2005 | 16 | 491 | Justin Smoak | 1b | Stratford (Goose Creek,SC) | Oakland | |
| 2005 | 16 | 495 | Yonder Alonso | c | Coral Gables High School (Coral Gables,FL) | Minnesota | |
| 2005 | 17 | 503 | James Russell | P | Navarro College | Seattle | |
| 2005 | 17 | 509 | Pedro Beato | P | Xaverian High School (Brooklyn, NY) | NY Mets | |
| 2005 | 17 | 519 | Chris Dominguez | 3B | Gulliver Prep (Coral Gables,FL) | Texas | |
| 2005 | 18 | 535 | Zach Braddock | P | Gloucester Catholic (Gloucester,NJ) | Milwaukee | |
| 2005 | 18 | 538 | Tommy Hunter | P | Cathedral (Indianapolis, IN) | Tampa Bay | |
| 2005 | 18 | 544 | Desmond Jennings | OF | Pinson Valley (Pinson, AL) | Cleveland | |
| 2005 | 18 | 551 | Anthony Recker | c | Alvernia University | Oakland | |
| 2005 | 19 | 568 | Ike Davis | 1b/lh | Chaparral High School (Scottsdale, AZ) | Tampa Bay | |
| 2005 | 19 | 570 | Burke Badenhop | P | Bowling Green State University | Detroit | |
| 2005 | 19 | 575 | Jordan Danks | OF | Round Rock (Round Rock,TX) | Chi. White Sox | |
| 2005 | 19 | 577 | David Huff | P | Cypress College | Philadelphia | |
| 2005 | 20 | 598 | Wade Miley | P | Loranger (Loranger,LA) | Tampa Bay | |
| 2005 | 20 | 607 | Vance Worley | P | McClatchy (Sacramento, CA) | Philadelphia | |
| 2005 | 20 | 617 | Andrew Cashner | P | Conroe (Conroe,TX) | Atlanta | |
| 2005 | 20 | 618 | Charlie Blackmon | P | Young Harris College | Boston | |
| 2005 | 21 | 627 | Chris Martin | P | McLennan Community College | Colorado | |
| 2005 | 21 | 630 | David Adams | SS | Grandview Preparatory School (Boca Raton, FL) | Detroit | |
| 2005 | 21 | 634 | Neil Wagner | P | North Dakota State University | Cleveland | |
| 2005 | 21 | 650 | Ryan Rohlinger | SS | University of Oklahoma | StL Cardinals | |
| 2005 | 22 | 665 | Christian Marrero | OF | Broward College | Chi. White Sox | |
| 2005 | 22 | 666 | Logan Morrison | 1b | Northshore (Slidell,LA) | Florida | |
| 2005 | 22 | 677 | Tommie Hanson | P | Riverside Community College | Atlanta | |
| 2005 | 22 | 680 | Jaime Garcia | P | StL Cardinals | ||
| 2005 | 23 | 688 | Danny Dorn | OF | Cal State Fullerton | Tampa Bay | |
| 2005 | 23 | 705 | Ken Herndon | P | Gulf Coast Community College | Minnesota | |
| 2005 | 25 | 741 | David Williams | OF | Rutgers University | Arizona | |
| 2005 | 25 | 745 | Taylor Green | 2b | Cypress College | Milwaukee | |
| 2005 | 25 | 748 | Clayton Mortensen | P | Treasure Valley Community College | Tampa Bay | |
| 2005 | 26 | 775 | Jacob Arrieta | P | Weatherford College | Milwaukee | |
| 2005 | 26 | 788 | Jon Link | P | Bluefield College | San Diego | |
| 2005 | 26 | 796 | Jordy Mercer | SS | Taloga (Taloga,OK) | LA Dodgers | |
| 2005 | 26 | 798 | Kirby Yates | P | Kauai (Lihue,HI) | Boston | |
| 2005 | 27 | 810 | Will Rhymes | 2b | College of William and Mary | Detroit | |
| 2005 | 27 | 814 | Brandon Laird | 1b | La Quinta High School (Westminster, CA) | Cleveland | |
| 2005 | 28 | 852 | Sergio Romo | P | Mesa State College | San Francisco | |
| 2005 | 28 | 857 | Harold Coleman | P | Pillow Academy (Greenwood,MS) | Atlanta | |
| 2005 | 29 | 873 | Tanner Scheppers | P | Dana Hills High School (Dana Point, CA) | Baltimore | |
| 2005 | 29 | 881 | Brad Kilby | P | San Jose State University | Oakland | |
| 2005 | 29 | 889 | Justin Turner | 2B | Cal State Fullerton | NY Yankees | |
| 2005 | 31 | 927 | Sean Halton | 1b | Fresno (Fresno, CA) | Colorado | |
| 2005 | 31 | 948 | Luis Exposito | c | Champagnat Catholic (Hialeah, FL) | Boston | |
| 2005 | 33 | 984 | Ryan Buchter | P | Highland Regional (Blackwood,NJ) | Washington | |
| 2005 | 33 | 1007 | Tyler Flowers | 1b | Chipola College | Atlanta | |
| 2005 | 33 | 1008 | John Hester | c | Stanford University | Boston | |
| 2005 | 34 | 1038 | Allan Dykstra | 1B | Rancho Bernardo High School (San Diego, CA) | Boston | |
| 2005 | 35 | 1062 | Antoan Richardson | OF | Vanderbilt University | San Francisco | |
| 2005 | 35 | 1063 | Chris Davis | 3b | Navarro College | LA Angels | |
| 2005 | 36 | 1095 | Rene Tosoni | OF | Chipola College | Minnesota | |
| 2005 | 38 | 1140 | Zach Putnam | P | Pioneer (Ann Arbor,MI) | Detroit | |
| 2005 | 39 | 1163 | Duke Welker | P | Seminole State College | Seattle | |
| 2005 | 40 | 1213 | Charlie Leesman | P | Elder (Cincinnati, OH) | Minnesota | |
| 2005 | 41 | 1222 | Tyler Moore | 1b | Northwest Rankin (Brandon,MS) | Washington | |
| 2005 | 42 | 1253 | Brett Wallace | 1B | Justin-Siena (Sonoma,CA) | Toronto | |
| 2005 | 42 | 1259 | John Axford | P | University of Notre Dame | Cincinnati | |
| 2005 | 42 | 1261 | Tim Lincecum | P | University of Washington | Cleveland | |
| 2005 | 42 | 1272 | Arnoldi Cruz | C | Northwest Florida State College | LA Dodgers | |
| 2005 | 43 | 1280 | Scott Barnes | P | Cathedral (Springfield,MA) | Washington | |
| 2005 | 43 | 1303 | Jason Castro | c | Castro Valley High School (Castro Valley, CA) | Boston | |
| 2005 | 44 | 1330 | Chase D'Arnaud | SS | Los Alamitos (Los Alamitos,CA) | LA Dodgers | |
| 2005 | 45 | 1362 | Brett Pill | 1B | Cal State Fullerton | NY Yankees | |
| 2005 | 46 | 1377 | Blake Davis | SS | Cal State Fullerton | Cleveland | |
| 2005 | 48 | 1429 | Jeremy Hefner | P | Seminole State College | NY Mets | |
| 2005 | 49 | 1455 | Joseph Coleman | P | Mariner High School (Cape Coral,FL) | Tampa Bay | |
| 2005 | 49 | 1469 | Anthony Vasquez | OF | Reagan High School (San Antonio, TX) | LA Angels | |
| 2005 | 50 | 1477 | Xavier Scruggs | 1B | Poway High School (Poway, CA) | Seattle | |
| 2005 | 50 | 1496 | Buster Posey | P | Lee County (Leesburg,GA) | LA Angels | |
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