The 2010 NFL season was the 91st regular season of the National Football League and the 45th of the Super Bowl era.
The regular season began with the NFL Kickoff game on NBC on Thursday, September 9, at the Louisiana Superdome as the New Orleans Saints, Super Bowl XLIV champions, defeated the Minnesota Vikings 14–9.
Tom Brady, quarterback of the New England Patriots, was named MVP for the 2010 season. In Super Bowl XLV, the League's championship game played at Cowboys Stadium in Arlington, Texas, the Green Bay Packers defeated the Pittsburgh Steelers 31–25 to win their fourth Super Bowl, spoiling the Steelers' chance for a 7th title. This season also marked the first full-length season in which a team with a losing record made the playoffs, when the Seattle Seahawks won the NFC West with a 7–9 record, after defeating the St. Louis Rams in week 17 to clinch the division title. One week later, the Seahawks dethroned the defending champion New Orleans Saints in the Wild Card round, to become the first ever sub-.500 playoff team to win a postseason game.
This season marked the last time a game was played on a Tuesday night until 2020.