The 1943 Major League Baseball season was contested from April 20 to October 11, 1943. The St. Louis Cardinals and New York Yankees were the regular season champions of the National League and American League, respectively. In a rematch of the prior year's postseason, the Yankees then defeated the Cardinals in the World Series, four games to one.
In order to conserve rail transport during World War II, the 1943 spring training was limited to an area east of the Mississippi River and north of the Ohio River. Spring training sites included the Chicago White Sox in French Lick, Indiana; the Washington Senators in College Park, Maryland; and the Yankees in Asbury Park, New Jersey.