The full 162-game regular season was originally scheduled to begin on March 26. However, the pandemic caused Major League Baseball (MLB) to announce on March 12 that the remainder of spring training was canceled and that the start of the regular season would be delayed by at least two weeks. On March 16, MLB announced that the season would be postponed indefinitely, following recommendations from the Centers for Disease Control and Prevention to restrict events of more than 50 people. This was the first time that MLB games have been put on hold since the 2001 season, when the season was paused for over a week after the September 11 attacks.
Spring training resumed on July 1 and was rebranded as "Summer Camp". On July 3, the All-Star Game was canceled because of the delay to the regular season. Dodger Stadium, which was set to host the game, will now host the 2022 All-Star Game.
On July 18, the Canadian federal government denied permission for the Toronto Blue Jays to play their home games at Rogers Centre this season on grounds that repeated cross-border trips by both the Blue Jays and their opponents would be a major risk due to the higher spikes in COVID-19 cases in the U.S. compared to those in Canada. The Blue Jays then chose to play their home games at Sahlen Field in Buffalo, home of their Triple-A affiliate Buffalo Bisons.
An expanded 16-team postseason tournament began on September 29, with games of all but the first round being played at neutral sites. The World Series began on October 20 at Globe Life Field in Arlington, and ended on October 27, with the Los Angeles Dodgers defeating the Tampa Bay Rays in six games to win their first title since 1988.